Erasca

VP Clinical Development & Global Program Lead, Lung Cancer

operationsfull-timeSan Diego, CA; South San Francisco, CA; remote

SALARY

$390k – $435k/yr

WORK TYPE

remote

JOB TYPE

full-time

INDUSTRY

healthcare

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About the role

<div class="content-intro">Erasca is a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s&nbsp;most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer.</div>Reporting to the Chief&nbsp;Medical&nbsp;Officer, the&nbsp;VP&nbsp;Clinical Development&nbsp;and Global Program&nbsp;Lead (GPL)&nbsp;for Lung Cancer will&nbsp;provide medical leadership and oversight of&nbsp;the&nbsp;lung cancer&nbsp;development&nbsp;program&nbsp;and collaborate with the CMO&nbsp;across the&nbsp;Erasca&nbsp;portfolio. Responsibilities will include clinical development strategy,&nbsp;protocol development, registrational&nbsp;strategy&nbsp;and execution, KOL and academic site interactions, competitive landscape diligence, presentation of data, and&nbsp;other clinical deliverables.&nbsp;In addition, the VP will be a&nbsp;hands–on drug developer and&nbsp;will&nbsp;serve as clinical lead and/or medical monitor on&nbsp;individual&nbsp;studies.&nbsp;&nbsp;

Essential Duties and Responsibilities:&nbsp;

<ul>

<li>Provide&nbsp;medical direction and high-quality scientific and clinical knowledge to guide the strategy and execution of&nbsp;the&nbsp;lung cancer&nbsp;program&nbsp;and&nbsp;contribute to clinical decision making across the&nbsp;Erasca&nbsp;portfolio.&nbsp;Participate in&nbsp;building&nbsp;and&nbsp;maintaining&nbsp;a culture of rigorous data-driven decision making.&nbsp;</li>

<li>Lead the clinical development&nbsp;subteam&nbsp;for all studies in lung&nbsp;cancers.&nbsp;</li>

<li>Design and implement&nbsp;novel and efficient&nbsp;clinical trials&nbsp;to&nbsp;assess&nbsp;appropriate endpoints.&nbsp;</li>

<li>Responsible for leading clinical study&nbsp;subteams,&nbsp;monitoring&nbsp;overall study integrity, and review, interpretation,&nbsp;and communication of safety and efficacy data.&nbsp;</li>

<li>Provide overall strategy for clinical aspects of registrational strategies, interactions, and filings. Contribute to global regulatory filings and health authority interactions, including authoring clinical sections for INDs,&nbsp;NDAs&nbsp;and other related documents.&nbsp;</li>

<li>Serve as&nbsp;Medical&nbsp;lead on clinical programs&nbsp;and represent Clinical Development on program teams.&nbsp;</li>

<li>Partner with Drug Safety to assess the safety profile of compounds.&nbsp;</li>

<li>Write&nbsp;or partner in the authoring of&nbsp;medical aspects of core study and regulatory documents including clinical research plans, protocols, investigator brochures, clinical study&nbsp;reports&nbsp;and regulatory submissions.&nbsp;&nbsp;</li>

<li>Contribute to the development and review of scientific publications; author manuscripts and collaborate with cross-functional colleagues and thought leaders to meet publication plan&nbsp;objectives.&nbsp;&nbsp;</li>

<li>Present at scientific, medical,&nbsp;and regulatory meetings.&nbsp;</li>

<li>Maintain&nbsp;a high level&nbsp;of clinical and scientific&nbsp;expertise&nbsp;by reviewing literature, attending medical&nbsp;or&nbsp;scientific meetings,&nbsp;and through personal&nbsp;exchange&nbsp;with&nbsp;thought leaders, investigators,&nbsp;and internal stakeholders&nbsp;and partners.&nbsp;</li>

<li>Participate in due diligence or other business development activities.&nbsp;</li>

<li>Hire, develop, and mentor a high functioning team of medical directors and clinical scientists.&nbsp;</li>

<li>Establish, develop,&nbsp;and&nbsp;maintain&nbsp;relationships across&nbsp;Erasca, particularly with partners and stakeholders in&nbsp;Research and&nbsp;Development.&nbsp;&nbsp;</li>

<li>Perform all duties in keeping with the Company’s core values,&nbsp;policies&nbsp;and all applicable regulations.&nbsp;</li>

</ul>

Required Education and Experience:&nbsp;

<ul>

<li>M.D.&nbsp;degree&nbsp;or equivalent, with subspecialty&nbsp;fellowship&nbsp;training and board certification or eligibility in Oncology or Oncology/Hematology&nbsp;required.&nbsp;Additional&nbsp;training and clinical practice&nbsp;experience&nbsp;in thoracic oncology preferred.&nbsp;</li>

<li>8-10+ years of&nbsp;oncology&nbsp;clinical trial and&nbsp;drug development experience,&nbsp;including extensive experience in the pharmaceutical or biotechnology industry.&nbsp;The ideal candidate will bring&nbsp;a combination of clinical practice, academic clinical trials,&nbsp;and industry experience,&nbsp;with&nbsp;both&nbsp;large and small company&nbsp;experience&nbsp;a plus.&nbsp;&nbsp;</li>

<li>Experience as the clinical lead on late-stage clinical programs in lung cancer highly preferred.&nbsp;</li>

<li>Experience leading or being&nbsp;closely involved&nbsp;in&nbsp;the clinical aspects of a&nbsp;regulatory filing and direct interaction with health authorities&nbsp;required.&nbsp;&nbsp;</li>

<li>Exposure to early development and the transition from FIH to registrational trials preferred.&nbsp;</li>

<li>Extensive knowledge of clinical trial&nbsp;methodology&nbsp;and the&nbsp;regulatory and compliance requirements governing clinical trials.&nbsp;&nbsp;</li>

<li>Demonstrated ability to collaborate successfully with multiple functions in a&nbsp;matrixed&nbsp;team environment.&nbsp;</li>

<li>Executive leadership skills to educate and influence stakeholders and to add value&nbsp;in&nbsp;strategic business planning and decision-making.&nbsp;&nbsp;</li>

<li>Effective interpersonal, communication and influencing skills, including excellent writing skills, with the ability to tailor communication style to diverse audiences and situations.&nbsp;&nbsp;</li>

<li>Demonstrated ability to achieve&nbsp;high performance&nbsp;goals and meet deadlines in a fast-paced environment; a collaborative team player with a can-do attitude and the ability to&nbsp;identify&nbsp;and implement creative solutions to complex problems.&nbsp;</li>

<li>Strong learning orientation, curiosity, and&nbsp;commitment to&nbsp;science and patients.&nbsp;</li>

</ul>

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