Senior Manager, Oncology Trial Navigation

About the Role

The Senior Manager of Oncology Trial Navigation will drive operational scalability and execution of our oncology trial navigation program, playing a critical role in supporting the connection of Signatera patients to appropriate clinical trial opportunities while focusing on strategic program growth and team leadership.

You will serve as the operational bridge between Natera’s centralized patient screening team and external stakeholders—including treating oncologists, principal investigators (PIs), research coordinators, and, when appropriate, patients themselves.

You will play a key role in operationalizing and scaling the oncology focused trial navigation program, partnering with internal stakeholders to harmonize best practices, refine clinical workflows, and scale the team’s reach. This is a unique opportunity for an experienced clinician to drive strategic development of a function that directly accelerates oncology clinical trial enrollment in a fast-scaling, mission driven environment. This role demands exceptional communication and cross functional collaboration to successfully deliver and expand clinical trial support in the oncology domain.

What You’ll Do

Physician & Site Engagement

• Deliver patient eligibility notifications and facilitate referral workflows.
• Support site prioritization and activation strategies.
• Ensure timely follow-up and outcome tracking.

Trial Matching Coordination

• Operationalize outputs from Natera’s AI-enabled trial matching platform.
• Support eligibility review by aligning molecular and clinical data with trial inclusion/exclusion criteria.
• Track patient progression from identification through referral and enrollment.

Patient & Caregiver Support (as applicable)

• Provide high-level, compliant education about trial opportunities.
• Coordinate seamless handoffs to site research teams.
• Approach all patient interactions with empathy and professionalism.

Operational Excellence

• Support business development by providing clinical feasibility insights.
• Maintain accurate documentation of outreach and referral activities.
• Use tracking tools to monitor performance metrics.
• Develop SOPs and continuous process improvement to support and scale operational excellence in Oncology Trial Navigation that are harmonized with existing Natera departments.
• Participate in cross-functional collaboration with Clinical Ops, Medical, Data Science, and Business Development.
• Proactively identify opportunities for process optimization, communication strategies, and contribute to organizational growth through development and implementation of operational strategy and best practices.

Leadership and Team Building

• Lead the hiring, onboarding, and professional development of Oncology Trial Navigation IC roles to scale this function.
• Provide direct coaching on clinical navigation, complex stakeholder management, and empathy-led patient trial matching.