Senior Director, Clinical Programs

Position Summary

The Senior Director of Clinical Programs will lead high-impact programs that advance GeneDx’s mission in rare disease diagnostics and precision medicine. This includes direct program ownership as well as managing a team of clinical program managers. This role is responsible for driving strategic initiatives within the Clinical Development team, including clinical research programs, medical input on product development, and regulatory support. The position requires strong leadership, deep expertise in clinical molecular genetics, and the ability to collaborate across internal teams and external stakeholders, including clinicians, academic collaborators, key opinion leaders (KOLs), and biopharma partners.

Job Responsibilities

• Evidence Generation Strategy: Support the design and execution of evidence generation strategies for established clinical programs that cover clinical settings and diseases/disorders of interest (e.g., neurodevelopmental disorders, inpatient rapid genomic testing, genomic newborn screening, and other clinical indications) in collaboration with R&D, Commercial, Regulatory, Market Access, and Operations teams. Spearhead strategic initiatives within Medical Affairs to support GeneDx’s growth and innovation goals.
• Design and Execution of Internal Clinical & Translational Research: Lead and oversee clinical research projects that utilize internal GeneDx data and align with established clinical programs. This includes the direct development and execution of projects within assigned clinical programs as well as oversight of a team of clinical program managers. Collaborate with internal partners, including clinical data scientists, health economics and outcomes researchers (HEOR), and Product, to design and execute projects. Project oversight includes ensuring strategic alignment of internal research projects with the broader evidence generation strategy, prioritization, resource allocation, and regular reporting to Medical Affairs/Clinical Development leadership as well as leading applicable study meetings.