Senior Bioinformatics Scientist

Primary Responsibilities

• Analyze complex genomic datasets leveraging scaled in-house pipelines, partnering cross-functionally with wet-lab scientists and statisticians to rapidly deliver data-driven answers to critical research goals.
• Architect, build, and deploy automated analysis pipelines for diagnostic tests, integrating robust capabilities for fusion detection, variant calling, and automated quality control metrics.
• Engineer novel genomic analysis tools and proactively identify optimization pathways to enhance pipeline accuracy and efficiency.
• Participate in code reviews, technical documentation, and the continuous improvement of core computational workflows.
• Coordinate directly with downstream infrastructure teams to ensure R&D tools scale efficiently into production systems.

Qualifications

• Ph.D. or Master's degree with a minimum of 5 years of professional experience in Bioinformatics, Computer Science, Engineering, Biochemistry, or a related quantitative field.

Knowledge, Skills, and Abilities

• Deep theoretical and practical understanding of high-throughput DNA sequence data analysis, including mapping, sequence alignment, and variant calling workflows.
• Advanced understanding of data structures, algorithm design, and computational complexity.
• Strong software engineering proficiency in Java or C++ within a professional production environment.
• Demonstrated scripting capability in Python or Perl for data manipulation, automation, and rapid prototyping.
• Deep expertise navigating Linux environments, utilizing command-line tools, and writing efficient shell scripts.
• Prior experience working with relational databases, particularly MySQL, is highly desirable.
• Demonstrated technical autonomy and rigorous data discipline when troubleshooting high-complexity algorithmic challenges.
• Excellent communication skills with a proven track record of explaining computational results clearly to cross-functional stakeholders.

Pay Transparency

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

Remote USA.

$117,400 — $146,800 USD.

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.