Executive Director, Scientific & Medical Excellence
About the role
What You'll Do
The Executive Director, Scientific & Medical Excellence is a senior leadership role within Medical Affairs, accountable for the cross-cutting scientific capabilities and programs that serve BridgeBio’s portfolio. This leader will own evidence generation planning, the investigator-sponsored trial (IST) and sponsored research portfolio, Medical Information, expanded access / compassionate use programs, and the integration of artificial intelligence into Medical Affairs ways of working—while driving global planning and alignment across affiliates and functions.
This individual will build and scale the operating model, governance, and standards that allow Medical Affairs to act with scientific rigor, speed, and compliance. The role requires deep expertise in rare disease, the maturity to lead in a matrixed, fast-paced environment, and the vision to modernize how a medical organization generates and exchanges scientific evidence. The role partners closely with Clinical Development, Regulatory, Commercial, Market Access, HEOR, Patient Advocacy, and Field Medical.
Responsibilities
Evidence Generation Planning
- Lead the development of the integrated evidence generation plan, in partnership with HEOR, aligned to overarching medical and asset strategy and informed by clearly prioritized scientific and stakeholder evidence gaps.
- Coordinate the planning of real-world evidence (RWE), registries, natural history studies, database analyses, and Phase 4 / post-marketing studies in partnership with Clinical Development, HEOR, and Biostatistics.
- Ensure evidence plans support regulatory interactions, value demonstration, payer engagement, and HTA requirements, and that data are disseminated through a coordinated publication strategy.
Investigator-Sponsored Trials (IST) & Sponsored Research Partnerships
- Own the strategy, governance, and end-to-end operations of the investigator-sponsored trial (IST) program, including the review committee, scientific prioritization, and funding decisions aligned to medical strategy and evidence gaps.
- Develop and manage sponsored research collaborations