Senior Director, Clinical Vendor Procurement and Management

About Us

We are developing potentially best in class therapies for patients living with severe autoimmune diseases. Our lead antibody, claseprubart (DNTH103), is purposefully engineered with extended half-life, improved potency, and high selectivity for only the active C1s complement protein that drives disease pathology – enabling less frequent and more convenient self-administered subcutaneous injections. Our second clinical candidate, DNTH212 is a first and potentially best in class, bifunctional inhibitor that targets clinically validated and complementary disease modifying mechanisms, Type 1 IFN suppression and B cell modulation – enabling potential for improved clinical outcomes and patient friendly convenient, self-administered subcutaneous injections.

About the Role

Reporting to the Sr. Vice President, Clinical Development Operations, the Sr. Director, Clinical Vendor Procurement and Management will lead Dianthus’ clinical outsourcing, vendor procurement, and vendor governance strategy across clinical development programs to drive organizational initiatives that improve business performance, operational efficiency, and execution excellence. This remote role will serve as a strategic business partner to Clinical Development Operations and other cross-functional stakeholders, ensuring vendor identification, selection, contracting, performance oversight, and spend management are executed efficiently, compliantly, and in alignment with program goals. The ideal candidate brings deep experience in clinical outsourcing, strong business acumen, and the ability to build high-value partnerships that support successful trial delivery.

We are building a culture of individuals who hold our core principles at the center of our operations, with the goal to elevate the care of our patients’ lives. We are open to you working remotely.

Key Responsibilities

• Lead the clinical vendor procurement and outsourcing strategy across development programs, partnering closely with Clinical Development Operations, Finance, Legal, and other stakeholders.
• Oversee end-to-end vendor selection activities, including RFI/RFP development, bid analysis, bid defense management, vendor recommendation, and onboarding.
• Negotiate and manage vendor scopes of work, budgets, contracts, change orders, and purchase order readiness to support timely study execution.
• Establish and maintain strong vendor governance processes, including KPIs, business reviews, issue escalation, and performance improvement plans.
• Drive cost optimization, spend visibility, forecasting, and financial discipline across vendor engagements while balancing quality, speed, and compliance.
• Partner with study teams and cross functional stakeholders to assess service needs, support sourcing decisions, and ensure vendor capabilities align with program and portfolio priorities.
• Develop and standardize procurement processes, tools, templates, and ways of working to enable scalable and efficient clinical operations.
• Monitor industry trends and best practices in clinical outsourcing, procurement, and vendor management to continuously improve Dianthus’ operating model.
• Develop clear, concise, and executive-ready communications, including presentations for senior leadership.

Experience

• Bachelor’s degree in business, life sciences, supply chain, or a related field; 15 years of experience in clinical procurement, strategic sourcing, outsourcing