Clinical Director, Oncology Clinical Development

What You’ll Do

Clinical & Program Leadership

• Serve as the program-level medical lead for Natera-sponsored MRD clinical trials across assigned oncology indications, with ultimate accountability for clinical outcomes, data integrity, and patient safety.
• Define clinical development strategies that align study design, endpoints, and execution with regulatory and scientific objectives.
• Provide medical oversight across the full trial lifecycle, from design and protocol development through first patient in (FPI), data readout, and study close-out.

Study Design & Execution

• Provide strategic and medical guidance to Clinical Scientists, fostering collaboration on protocol design, data interpretation, and translational insights that drive clinical program success.
• Act as Medical Monitor, overseeing safety signal detection, adverse event review, and risk mitigation in compliance with GCP and regulatory requirements.

Cross-functional Leadership

• Partner cross-functionally with Clinical Science, Clinical Operations, Data Management and Biostatistics to ensure timely and successful study execution, operational feasibility, and data quality.
• Collaborate with Regulatory Affairs to support submissions, regulatory interactions, and responses, as appropriate.

Scientific & External Engagement

• Represent Natera as the clinical development lead in interactions with investigators, key opinion leaders, IRBs, and regulatory authorities.
• Guide interpretation of interim and final analyses, ensuring scientific accuracy and clinical relevance.
• Provide strategic leadership for clinical study r